Figure 7

Expression and function of P-gp in C2, TR1, TR2, and TR3 cells (A) Western blot analysis of P-gp expression in at 240 and 1060 second exposures and (B) Rhodamine efflux/uptake assay in the same cells as A. Administration of the P-gp inhibitor, verapamil, increases fluorescence signal in lines with functional P-gp (MDCK-MDR1) with relatively no change in signal in lines without functional P-gp (C2, TR1, TR2, TR3).