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Table 3 Effect of metoclopramide on open-field activity and tonic immobility test in chicks

From: Metoclopramide-induced central nervous system depression in the chicken

Metoclopramide (mg/kg, subcutaneously) Squares crossed/5 minutes Duration of immobility (second)
0 (saline-control) 3.5 ± 1.4 10.5 ± 2.7
5 1.0 ± 1.0* 54.9 ± 18.1
10 0.1 ± 0.1* 130.6 ± 26.3*†
  1. Open-field activity was measured 20 min after drug administration. Tonic immobility test was done immediately after the open-field test.
  2. Values are mean ± SE of 8 chicks/group.
  3. * Significantly different from the respective control values, P < 0.05.
  4. † Significantly different from the 5 mg/kg treatment group, P < 0.05.