Table 2 Determination of median effective doses (ED50) of metoclopramide for induction of sedation and sleep (loss of righting reflex) in chicks by the up-and-down method*
From: Metoclopramide-induced central nervous system depression in the chicken
Variable | Result |
|---|---|
Sedation | |
ED50 | 11 mg/kg, subcutaneously (s.c.) |
Range of the doses used | 25-5 = 20 mg/kg, s.c. |
Initial dose | 25 mg/kg, s.c. |
Last dose | 10 mg/kg, s.c. |
Number of chicks used | 8 (XXXXOOXO) |
Increase or decrease in the dose | 5 mg/kg, s.c. |
Range of latency to induce sedation | 20-5 = 15 minutes |
Range of duration of sedation | 44-7 = 37 minutes |
Sleep | |
ED50 | 53 mg/kg, s.c. |
Range of the doses used | 100-50 = 50 mg/kg, s.c. |
Initial dose | 100 mg/kg, s.c. |
Last dose | 60 mg/kg, s.c. |
Number of chicks used | 9 (XXXXXOXOX) |
Increase or decrease in the dose | 10 mg/kg, s.c. |
Range of latency to induce sleep | 12-2 = 10 minutes |
Range of duration of sleep | 67-11 = 56 minutes |