Skip to main content

Table 2 Determination of median effective doses (ED50) of metoclopramide for induction of sedation and sleep (loss of righting reflex) in chicks by the up-and-down method*

From: Metoclopramide-induced central nervous system depression in the chicken

Variable Result
Sedation  
ED50 11 mg/kg, subcutaneously (s.c.)
Range of the doses used 25-5 = 20 mg/kg, s.c.
Initial dose 25 mg/kg, s.c.
Last dose 10 mg/kg, s.c.
Number of chicks used 8 (XXXXOOXO)
Increase or decrease in the dose 5 mg/kg, s.c.
Range of latency to induce sedation 20-5 = 15 minutes
Range of duration of sedation 44-7 = 37 minutes
Sleep  
ED50 53 mg/kg, s.c.
Range of the doses used 100-50 = 50 mg/kg, s.c.
Initial dose 100 mg/kg, s.c.
Last dose 60 mg/kg, s.c.
Number of chicks used 9 (XXXXXOXOX)
Increase or decrease in the dose 10 mg/kg, s.c.
Range of latency to induce sleep 12-2 = 10 minutes
Range of duration of sleep 67-11 = 56 minutes
  1. *Dixon [18].
  2. X = sedation or sleep; O = no sedation or sleep