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Table 1 Metoclopramide -induced sedation and sleep (loss of righting reflex) in chicks

From: Metoclopramide-induced central nervous system depression in the chicken

Metoclopramide (mg/kg, subcutaneously) Latency to onset of sedation (minute) Latency to onset of sleep (minute) Duration of sedation (minute) Duration of sleep (minute) Recovery time (minute)
50 19.0 ± 2.2 none 37.2 ± 7.6 none 43.4 ± 7.8
100 8.8 ± 2.5* 12.2 ± 2.2 66.4 ± 5.5* 43.8 ± 3.5 74.6 ± 6.4*
200 3.6 ± 0.5* 6.2 ± 0.5† 163.4 ± 17.4*† 158.6 ± 23.3*† 168.4 ± 16.6*†
  1. Values are mean ± SE of 5 chicks/group.
  2. * Significantly different from the 50 mg/kg treatment group, P < 0.05.
  3. † Significantly different from the 100 mg/kg treatment group, P < 0.05.
  4. A control group of chicks was also treated with physiological saline solution (5 ml/kg, subcutaneously).