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Table 1 Metoclopramide -induced sedation and sleep (loss of righting reflex) in chicks

From: Metoclopramide-induced central nervous system depression in the chicken

Metoclopramide (mg/kg, subcutaneously)

Latency to onset of sedation (minute)

Latency to onset of sleep (minute)

Duration of sedation (minute)

Duration of sleep (minute)

Recovery time (minute)

50

19.0 ± 2.2

none

37.2 ± 7.6

none

43.4 ± 7.8

100

8.8 ± 2.5*

12.2 ± 2.2

66.4 ± 5.5*

43.8 ± 3.5

74.6 ± 6.4*

200

3.6 ± 0.5*

6.2 ± 0.5†

163.4 ± 17.4*†

158.6 ± 23.3*†

168.4 ± 16.6*†

  1. Values are mean ± SE of 5 chicks/group.
  2. * Significantly different from the 50 mg/kg treatment group, P < 0.05.
  3. † Significantly different from the 100 mg/kg treatment group, P < 0.05.
  4. A control group of chicks was also treated with physiological saline solution (5 ml/kg, subcutaneously).
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BMC Veterinary Research

ISSN: 1746-6148

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