Figure 1

The nucleotide and deduced amino acid sequences of Sus scrofa CD11a cDNA. The putative leader peptide and transmembrane region are respectively represented by green and dark blue boxes. The αI-domain is showed by a yellow box. Its five-stranded β-sheets and seven α-helices are underlined. Its metal-ion dependent adhesion site (MIDAS) is represented by red boxes. The sequences of the seven repeats that surround the αI-domain are framed. Light blue boxes represent the central divalent cation-binding motifs (DCBM) of the three COOH-terminal repeats. The important Glu-333 residue (E) and the supplementary Gln-744 (Q) are in black boxes. The conserved sequence "GFFKR" of the cytoplasmic tail, near the transmembrane region, is in a dark grey box. Cysteine residues (¤), potential N-glycosylation sites (#) and potential cytoplasmic-tail phosphorylation sites (+) are marked at the top of the sequences. Seven independent clones were sequenced in both directions. Sequence data have been deposited at GenBank under accession nos. DQ013285 and DQ013284 (shown here). Both sequences differ by a glutamine deletion in position 744 in sequence DQ013284.