Section edited by Cheryl London

The oncology section publishes research findings which focus on studies that address the etiology and treatment of cancer in veterinary patients. We consider studies on cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology

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  1. Research article

    Retrospective clinical study on outcome in cats with nasal planum squamous cell carcinoma treated with an accelerated radiation protocol

    Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a v...

    Evgeniya Gasymova, Valeria Meier, Franco Guscetti, Simona Cancedda, Malgorzata Roos and Carla Rohrer Bley

    BMC Veterinary Research 2017 13:86

    Published on: 4 April 2017

  2. Research article

    A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions

    Canine mammary tumors represent the most common neoplasm in female dogs, and the discovery of cancer biomarkers and their translation to clinical relevant assays is a key requirement in the war on cancer. Sinc...

    Giovanni Pietro Burrai, Alessandro Tanca, Tiziana Cubeddu, Marcello Abbondio, Marta Polinas, Maria Filippa Addis and Elisabetta Antuofermo

    BMC Veterinary Research 2017 13:38

    Published on: 31 January 2017

  3. Research article

    Prognostic efficacy of the human B-cell lymphoma prognostic genes in predicting disease-free survival (DFS) in the canine counterpart

    Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkin’s lymphoma where the lymphomas of both species share similar clinical features and biological behaviors. However there are some differences ...

    Mohamad Zamani-Ahmadmahmudi, Sina Aghasharif and Keyhan Ilbeigi

    BMC Veterinary Research 2017 13:17

    Published on: 9 January 2017

  4. Research article

    Neoplastic diseases in the domestic ferret (Mustela putorius furo) in Italy: classification and tissue distribution of 856 cases (2000–2010)

    The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan.

    Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi and Paola Roccabianca

    BMC Veterinary Research 2016 12:275

    Published on: 5 December 2016

  5. Research article

    A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

    Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulatio...

    Janet A. Grimes, Nripesh Prasad, Shawn Levy, Russell Cattley, Stephanie Lindley, Harry W. Boothe, Ralph A. Henderson and Bruce F. Smith

    BMC Veterinary Research 2016 12:272

    Published on: 3 December 2016

  6. Research article

    Ultrasonographic features of adrenal gland lesions in dogs can aid in diagnosis

    Ultrasonography to visualize adrenal gland lesions and evaluate incidentally discovered adrenal masses in dogs has become more reliable with advances in imaging techniques. However, correlations between sonogr...

    Elena Pagani, Massimiliano Tursi, Chiara Lorenzi, Alberto Tarducci, Barbara Bruno, Enrico Corrado Borgogno Mondino and Renato Zanatta

    BMC Veterinary Research 2016 12:267

    Published on: 28 November 2016

  7. Research article

    A pilot study of toceranib/vinblastine therapy for canine transitional cell carcinoma

    Effective therapies for transitional cell carcinoma (TCC) are limited, with objective response rates to most chemotherapeutic regimens below 20%. The purpose of this study was to investigate the biologic activ...

    Sarah B. Rippy, Heather L. Gardner, Sandra M. Nguyen, Emma E. Warry, Roberta F. Portela, William Tod Drost, Eric T. Hostnik, Eric M. Green, Dennis J. Chew, Juan Peng and Cheryl A. London

    BMC Veterinary Research 2016 12:257

    Published on: 17 November 2016

    The Erratum to this article has been published in BMC Veterinary Research 2016 12:291

  8. Case Report

    Pulmonary carcinoma with metastasis in a long-finned pilot whale (Globicephala melas)

    Lung cancer is the most commonly diagnosed neoplasm in humans, however this does not apply to other animal species. Living in an aquatic environment the respiratory system of cetaceans had to undergo unique ad...

    Cristian M. Suárez-Santana, Carolina Fernández-Maldonado, Josué Díaz-Delgado, Manuel Arbelo, Alejandro Suárez-Bonnet, Antonio Espinosa de los Monteros, Nakita Câmara, Eva Sierra and Antonio Fernández

    BMC Veterinary Research 2016 12:229

    Published on: 11 October 2016

  9. Research article

    Comprehensive genomic characterization of five canine lymphoid tumor cell lines

    Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the prima...

    Sarah C. Roode, Daniel Rotroff, Kristy L. Richards, Peter Moore, Alison Motsinger-Reif, Yasuhiko Okamura, Takuya Mizuno, Hajime Tsujimoto, Steven E. Suter and Matthew Breen

    BMC Veterinary Research 2016 12:207

    Published on: 17 September 2016

  10. Research article

    Significance of EZH2 expression in canine mammary tumors

    Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits...

    Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong and Woo-Chan Son

    BMC Veterinary Research 2016 12:164

    Published on: 9 August 2016

  11. Research article

    Effects and synergy of feed ingredients on canine neoplastic cell proliferation

    Adjunctive use of nutraceuticals in human cancer has shown promise, but little work has been done in canine neoplasia. Previous human research has shown that polyphenols and carotenoids can target multiple pat...

    Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    BMC Veterinary Research 2016 12:159

    Published on: 2 August 2016

  12. Case Report

    Diagnosis and surgical management of malignant ovarian teratoma in a green iguana (Iguana iguana)

    Ovarian tumors in reptiles are uncommonly reported in the literature and for green iguanas previously reported cases include teratomas, one adenocarcinoma and one papillary cystadenocarcinoma. The present repo...

    Lucia Bel, Marco Tecilla, Gabriel Borza, Cosmin Pestean, Robert Purdoiu, Ciprian Ober, Liviu Oana and Marian Taulescu

    BMC Veterinary Research 2016 12:144

    Published on: 19 July 2016

  13. Research article

    Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro

    Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used...

    Milan Milovancev, Stuart C. Helfand, Kevin Marley, Cheri P. Goodall, Christiane V. Löhr and Shay Bracha

    BMC Veterinary Research 2016 12:85

    Published on: 4 June 2016

  14. Research article

    Extracellular matrix remodeling in equine sarcoid: an immunohistochemical and molecular study

    Equine sarcoids are locally invasive, fibroblastic benign skin tumors. Bovine papillomavirus type-1 (BPV-1) and/or Bovine papillomavirus type-2 (BPV-2) are believed to be the causative agent of sarcoids, altho...

    Manuela Martano, Annunziata Corteggio, Brunella Restucci, Maria Ester De Biase, Giuseppe Borzacchiello and Paola Maiolino

    BMC Veterinary Research 2016 12:24

    Published on: 2 February 2016

  15. Research article

    Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

    Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence selective DNA mi...

    Maria Mellinas-Gomez, Victoria J. Spanswick, Solange R. Paredes-Moscosso, Matthew Robson, R. Barbara Pedley, David E. Thurston, Stephen J. Baines, Anneliese Stell and John A. Hartley

    BMC Veterinary Research 2015 11:215

    Published on: 19 August 2015

  16. Research article

    Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma

    Signal transducer and activator of transcription 3 (STAT3) plays a critical role in tumor development by regulating signaling pathways involved in cell proliferation, survival, metastasis and angiogenesis. STA...

    Megan E. Brown, Misty D. Bear, Thomas J. Rosol, Chris Premanandan, William C. Kisseberth and Cheryl A. London

    BMC Veterinary Research 2015 11:206

    Published on: 14 August 2015

  17. Research article

    Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma

    Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing...

    Silvia Guil-Luna, Jan Stenvang, Nils Brünner, Francisco Javier De Andrés, Eva Rollón, Víctor Domingo, Raquel Sánchez-Céspedes, Yolanda Millán and Juana Martín de las Mulas

    BMC Veterinary Research 2014 10:296

    Published on: 17 December 2014

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