Clinical pathology, physiology and immunology

Section edited by Jose Joaquin Ceron

The clinical pathology, physiology and immunology section covers a broad range of studies regarding the physiological processes that occur in healthy animals and the animals’ response to stress and different diseases such as infectious diseases. This section considers research articles on biomarkers; biochemistry; cytopathology; endocrinology; pathophysiology; proteomics; hematopathology; immunology amd molecular diagnostics

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  1. Research article

    Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

    Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different prese...

    Martina Crnogaj, José Joaquin Cerón, Iva Šmit, Ivana Kiš, Jelena Gotić, Mirna Brkljačić, Vesna Matijatko, Camila Peres Rubio, Nada Kučer and Vladimir Mrljak

    BMC Veterinary Research 2017 13:114

    Published on: 24 April 2017

  2. Research article

    Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

    Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of...

    Romy M. Heilmann, Elizabeth A. McNiel, Niels Grützner, David J. Lanerie, Jan S. Suchodolski and Jörg M. Steiner

    BMC Veterinary Research 2017 13:112

    Published on: 21 April 2017

  3. Research article

    Revelation of mRNAs and proteins in porcine milk exosomes by transcriptomic and proteomic analysis

    Milk is a complex liquid that provides nutrition to newborns. Recent reports demonstrated that milk is enriched in maternal-derived exosomes that are involved in fetal physiological and pathological conditions...

    Ting Chen, Qian-Yun Xi, Jia-Jie Sun, Rui-Song Ye, Xiao Cheng, Rui-Ping Sun, Song-Bo Wang, Gang Shu, Li-Na Wang, Xiao-Tong Zhu, Qing-Yan Jiang and Yong-Liang Zhang

    BMC Veterinary Research 2017 13:101

    Published on: 13 April 2017

  4. Research article

    Variation in fat content between liver lobes and comparison with histopathological scores in dairy cows with fatty liver

    The assessment of a liver biopsy remains the gold standard for diagnosing and staging fatty liver in dairy cows, which is often necessary for diagnostic and research purposes. Accuracy of the diagnosis relays ...

    C. Gerspach, S. Imhasly, R. Klingler, M. Hilbe, S. Hartnack and M. Ruetten

    BMC Veterinary Research 2017 13:98

    Published on: 12 April 2017

  5. Research article

    Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats

    There are two biotypes of feline coronavirus (FCoV): the self-limiting feline enteric coronavirus (FECV) and the feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP), a ...

    Nikoo Safi, Amin Haghani, Shing Wei Ng, Gayathri Thevi Selvarajah, Farina Mustaffa-Kamal and Abdul Rahman Omar

    BMC Veterinary Research 2017 13:92

    Published on: 7 April 2017

  6. Research article

    Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

    Synovitis is an inflammation-related disease linked to rheumatoid arthritis, osteoarthritis, infections and trauma. This inflammation is accompanied by immune cells infiltration which initiates an inflammatory...

    Francisco-Javier Vela, Francisco-Miguel Sánchez-Margallo, Rebeca Blázquez, Verónica Álvarez, Raquel Tarazona, M. Teresa Mangas-Ballester, Alejandro Cristo and Javier G. Casado

    BMC Veterinary Research 2017 13:93

    Published on: 7 April 2017

  7. Research article

    Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

    Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles ...

    Rizaldy C. Zapata, Melissa D. Meachem, Natalia Cavalca Cardoso, Susan O. Mehain, Chantal J. McMillan, Elisabeth R. Snead and Prasanth K. Chelikani

    BMC Veterinary Research 2017 13:85

    Published on: 4 April 2017

  8. Research article

    Blood markers of fibrinolysis and endothelial activation in canine babesiosis

    Canine babesiosis is a tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. The disease can be clinically classified into uncomplicated and complicated forms. The aim of this study was to as...

    Josipa Kuleš, Jelena Gotić, Vladimir Mrljak and Renata Barić Rafaj

    BMC Veterinary Research 2017 13:82

    Published on: 31 March 2017

  9. Research article

    Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care

    Studies suggest that free-ranging bottlenose dolphins exhibit a suppressed immune system because of exposure to contaminants or microorganisms. However, due to a lack of commercially available antibodies speci...

    Mahyar Nouri-Shirazi, Brittany F. Bible, Menghua Zeng, Saba Tamjidi and Gregory D. Bossart

    BMC Veterinary Research 2017 13:78

    Published on: 27 March 2017

  10. Research article

    Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae

    Actinobacillus (A.) pleuropneumoniae is the causative agent of porcine pleuropneumonia and causes significant losses in the pig industry worldwide. Early host immune response is crucia...

    Elena L. Sassu, Janna Frömbling, J. Catharina Duvigneau, Ingrid Miller, Andrea Müllebner, Ana M. Gutiérrez, Tom Grunert, Martina Patzl, Armin Saalmüller, Alexandra von Altrock, Anne Menzel, Martin Ganter, Joachim Spergser, Marion Hewicker-Trautwein, Jutta Verspohl, Monika Ehling-Schulz…

    BMC Veterinary Research 2017 13:64

    Published on: 28 February 2017

  11. Research article

    Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis

    One of the most commonly applied protectotype vaccination protocol against infectious bronchitis (IB) in broiler chickens in the EU is simultaneous or alternate use of Ma5 and 4/91 vaccine strains. After IB va...

    Marcin Smialek, Bartlomiej Tykalowski, Daria Dziewulska, Tomasz Stenzel and Andrzej Koncicki

    BMC Veterinary Research 2017 13:44

    Published on: 8 February 2017

  12. Research article

    Serum proteomic profiles in CKCS with Mitral valve disease

    Myxomatous mitral valve disease (MVD) is the most common acquired heart disease in dogs, and the Cavalier King Charles Spaniel (CKCS) is the most studied breed because of the high prevalence, early onset and h...

    Chiara Locatelli, Cristian Piras, Giulia Riscazzi, Isabella Alloggio, Ilaria Spalla, Alessio Soggiu, Viviana Greco, Luigi Bonizzi, Paola Roncada and Paola G. Brambilla

    BMC Veterinary Research 2017 13:43

    Published on: 7 February 2017

  13. Research article

    Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment

    The objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other differen...

    Luis Pardo-Marín, Silvia Martínez-Subiela, Josep Pastor, Asta Tvarijonaviciute, Juan Diego Garcia-Martinez, Sergi Segarra and José Joaquín Cerón

    BMC Veterinary Research 2017 13:31

    Published on: 23 January 2017

  14. Research article

    The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

    The similarities between swine and humans in physiological and genomic patterns, and the great correlation in size and anatomy, make pigs extremely useful in preclinical studies. New-born piglets can represent...

    Domenico Ventrella, Francesco Dondi, Francesca Barone, Federica Serafini, Alberto Elmi, Massimo Giunti, Noemi Romagnoli, Monica Forni and Maria L. Bacci

    BMC Veterinary Research 2017 13:23

    Published on: 17 January 2017

  15. Research article

    Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

    Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there ...

    R. Barić Rafaj, J. Kuleš, A. Marinculić, A. Tvarijonaviciute, J. Ceron, Ž. Mihaljević, A. Tumpa and V. Mrljak

    BMC Veterinary Research 2017 13:13

    Published on: 6 January 2017

  16. Research article

    Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA

    The aims of the current study were to evaluate the inflammatory response in cow uterus and to explore the molecular mechanism triggered by high concentrate-induced subacute ruminal acidosis (SARA) in mid-lacta...

    Muhammad Shahid Bilal, Juma Ahamed Abaker, Zain ul Aabdin, Tianle Xu, Hongyu Dai, Kai Zhang, Xinxin Liu and Xiangzhen Shen

    BMC Veterinary Research 2016 12:284

    Published on: 12 December 2016

  17. Research article

    Development of an ovine efferent mammary lymphatic cannulation model with minimal tissue damage

    Two mammary lymphatic cannulation models in sheep have been described with minimal use in the past 50 years. The purpose of this study was to investigate a new surgical technique to allow long term monitoring ...

    Hung-Hsun Yen, Elizabeth Washington, Wayne Kimpton, Evan Hallein, Joanne Allen, Silk Yu Lin and Stuart Barber

    BMC Veterinary Research 2016 12:285

    Published on: 12 December 2016

  18. Research article

    Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

    Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for s...

    Crystal R. Sundburg, Janelle M. Belanger, Danika L. Bannasch, Thomas R. Famula and Anita M. Oberbauer

    BMC Veterinary Research 2016 12:278

    Published on: 8 December 2016

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