Clinical pathology, physiology and immunology

Section edited by Jose Joaquin Ceron

The clinical pathology, physiology and immunology section covers a broad range of studies regarding the physiological processes that occur in healthy animals and the animals’ response to stress and different diseases such as infectious diseases. This section considers research articles on biomarkers; biochemistry; cytopathology; endocrinology; pathophysiology; proteomics; hematopathology; immunology amd molecular diagnostics

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  1. Research article

    Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care

    Studies suggest that free-ranging bottlenose dolphins exhibit a suppressed immune system because of exposure to contaminants or microorganisms. However, due to a lack of commercially available antibodies speci...

    Mahyar Nouri-Shirazi, Brittany F. Bible, Menghua Zeng, Saba Tamjidi and Gregory D. Bossart

    BMC Veterinary Research 2017 13:78

    Published on: 27 March 2017

  2. Research article

    Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae

    Actinobacillus (A.) pleuropneumoniae is the causative agent of porcine pleuropneumonia and causes significant losses in the pig industry worldwide. Early host immune response is crucia...

    Elena L. Sassu, Janna Frömbling, J. Catharina Duvigneau, Ingrid Miller, Andrea Müllebner, Ana M. Gutiérrez, Tom Grunert, Martina Patzl, Armin Saalmüller, Alexandra von Altrock, Anne Menzel, Martin Ganter, Joachim Spergser, Marion Hewicker-Trautwein, Jutta Verspohl, Monika Ehling-Schulz…

    BMC Veterinary Research 2017 13:64

    Published on: 28 February 2017

  3. Research article

    Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis

    One of the most commonly applied protectotype vaccination protocol against infectious bronchitis (IB) in broiler chickens in the EU is simultaneous or alternate use of Ma5 and 4/91 vaccine strains. After IB va...

    Marcin Smialek, Bartlomiej Tykalowski, Daria Dziewulska, Tomasz Stenzel and Andrzej Koncicki

    BMC Veterinary Research 2017 13:44

    Published on: 8 February 2017

  4. Research article

    Serum proteomic profiles in CKCS with Mitral valve disease

    Myxomatous mitral valve disease (MVD) is the most common acquired heart disease in dogs, and the Cavalier King Charles Spaniel (CKCS) is the most studied breed because of the high prevalence, early onset and h...

    Chiara Locatelli, Cristian Piras, Giulia Riscazzi, Isabella Alloggio, Ilaria Spalla, Alessio Soggiu, Viviana Greco, Luigi Bonizzi, Paola Roncada and Paola G. Brambilla

    BMC Veterinary Research 2017 13:43

    Published on: 7 February 2017

  5. Research article

    Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment

    The objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other differen...

    Luis Pardo-Marín, Silvia Martínez-Subiela, Josep Pastor, Asta Tvarijonaviciute, Juan Diego Garcia-Martinez, Sergi Segarra and José Joaquín Cerón

    BMC Veterinary Research 2017 13:31

    Published on: 23 January 2017

  6. Research article

    The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

    The similarities between swine and humans in physiological and genomic patterns, and the great correlation in size and anatomy, make pigs extremely useful in preclinical studies. New-born piglets can represent...

    Domenico Ventrella, Francesco Dondi, Francesca Barone, Federica Serafini, Alberto Elmi, Massimo Giunti, Noemi Romagnoli, Monica Forni and Maria L. Bacci

    BMC Veterinary Research 2017 13:23

    Published on: 17 January 2017

  7. Research article

    Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

    Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there ...

    R. Barić Rafaj, J. Kuleš, A. Marinculić, A. Tvarijonaviciute, J. Ceron, Ž. Mihaljević, A. Tumpa and V. Mrljak

    BMC Veterinary Research 2017 13:13

    Published on: 6 January 2017

  8. Research article

    Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA

    The aims of the current study were to evaluate the inflammatory response in cow uterus and to explore the molecular mechanism triggered by high concentrate-induced subacute ruminal acidosis (SARA) in mid-lacta...

    Muhammad Shahid Bilal, Juma Ahamed Abaker, Zain ul Aabdin, Tianle Xu, Hongyu Dai, Kai Zhang, Xinxin Liu and Xiangzhen Shen

    BMC Veterinary Research 2016 12:284

    Published on: 12 December 2016

  9. Research article

    Development of an ovine efferent mammary lymphatic cannulation model with minimal tissue damage

    Two mammary lymphatic cannulation models in sheep have been described with minimal use in the past 50 years. The purpose of this study was to investigate a new surgical technique to allow long term monitoring ...

    Hung-Hsun Yen, Elizabeth Washington, Wayne Kimpton, Evan Hallein, Joanne Allen, Silk Yu Lin and Stuart Barber

    BMC Veterinary Research 2016 12:285

    Published on: 12 December 2016

  10. Research article

    Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

    Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for s...

    Crystal R. Sundburg, Janelle M. Belanger, Danika L. Bannasch, Thomas R. Famula and Anita M. Oberbauer

    BMC Veterinary Research 2016 12:278

    Published on: 8 December 2016

  11. Research article

    Biochemical and proteomic analyses of the physiological response induced by individual housing in gilts provide new potential stress markers

    The objective assessment of animal stress and welfare requires proper laboratory biomarkers. In this work, we have analyzed the changes in serum composition in gilts after switching their housing, from pen to ...

    Anna Marco-Ramell, Laura Arroyo, Raquel Peña, Raquel Pato, Yolanda Saco, Lorenzo Fraile, Emøke Bendixen and Anna Bassols

    BMC Veterinary Research 2016 12:265

    Published on: 25 November 2016

  12. Research article

    Bovine lactoferrin free of lipopolysaccharide can induce a proinflammatory response of macrophages

    Lactoferrin (LF) is an 80 kDa glycoprotein which is known for its effects against bacteria, viruses and other pathogens. It also has a high potential in nutrition therapy and welfare of people and a variety of...

    Nada Zemankova, Katarina Chlebova, Jan Matiasovic, Jana Prodelalova, Jan Gebauer and Martin Faldyna

    BMC Veterinary Research 2016 12:251

    Published on: 10 November 2016

  13. Research article

    Modulating effects of exercise training regimen on skeletal muscle properties in female polo ponies

    The match play patterns in equestrian polo are unique and require specific training programs to ensure sport performance. The effect of commonly used exercise training regimens on the adaptation of skeletal mu...

    Metha Chanda, Ratchakrit Srikuea, Worakij Cherdchutam, Arthit Chairoungdua and Pawinee Piyachaturawat

    BMC Veterinary Research 2016 12:245

    Published on: 4 November 2016

  14. Methodology article

    Development and validation of an assay for measurement of leptin in pig saliva

    Leptin has been measured in human in saliva samples. However, the low leptin concentration found in this biological fluid makes necessary the use of high sensitive methods. To the authors’ knowledge, leptin ha...

    Elizabeth M. S. Schmidt, Damián Escribano, Silvia Martinez-Subiela, Silvia Martinez-Miró, Fuensanta Hernández, Asta Tvarijonaviciute, José J. Cerón and Fernando Tecles

    BMC Veterinary Research 2016 12:242

    Published on: 28 October 2016

  15. Research article

    Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge

    Sepsis is a serious health problem associated with a range of infectious diseases in animals and humans. Early events of this syndrome can be mimicked by experimental administration of lipopolysaccharides (LPS...

    Øyvind Salvesen, Malin R. Reiten, Peter M. H. Heegaard, Michael A. Tranulis, Arild Espenes, Kerstin Skovgaard and Cecilie Ersdal

    BMC Veterinary Research 2016 12:241

    Published on: 28 October 2016

  16. Research article

    Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

    In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic te...

    Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall and Mads Kjelgaard-Hansen

    BMC Veterinary Research 2016 12:240

    Published on: 28 October 2016

  17. Research article

    Multicentric lymphoma in buffaloes in the Amazon region, Brazil

    The presence of lymphoma in buffaloes was first reported in India in the 1960s. The disease is similar to Enzootic Bovine Leucosis (EBL) caused by Bovine leukemia virus (BLV) in cattle; however, according to our ...

    Cairo H S De Oliveira, José D Barbosa, Karine A Damasceno, Geovanni D Cassali, Carlos MC Oliveira, Rômulo C Leite and Jenner K P Reis

    BMC Veterinary Research 2016 12:238

    Published on: 20 October 2016

  18. Research article

    Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages

    The neonatal Fc receptor (FcRn) plays a crucial role in transporting IgG and associated antigens across polarized epithelial barriers in mucosal immunity. However, it was not clear that FcRn expression in aggr...

    Wang-Dong Zhang, Wen-Hui Wang, Shu-Xian Li, Shuai Jia, Xue-Feng Zhang and Ting-Ting Cao

    BMC Veterinary Research 2016 12:237

    Published on: 20 October 2016

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