Skip to main content

Table 3 PK/PD analysis and AUC24h/MIC ratio values of gamithromycin necessary to achieve the bacteriostatic, bactericidal and eradication effects against P. multocida CVCC 434 in rabbit plasma

From: Pharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis

PK/PD parameters a

Units

Mean ± SD b

E0

log10 cfu/mL

2.42 ± 0.38

Emax

log10 cfu/mL

-5.37 ± 0.01

Emax - E0

log10 cfu/mL

-7.51 ± 0.11

EC50

h

19.5 ± 1.59

N

NA

4.12 ± 0.67

AUC24h/MIC for bacteriostatic

h

15.4 ± 1.79

AUC24h/MIC for bactericidal

h

24.9 ± 2.25

AUC24h/MIC for eradication

h

27.8 ± 0.52

  1. a E0, the change in bacterial count after 24 h of incubation in control plasma; EC50, the AUC24h/MIC ratio associated with 50% of the maximal activity (Emax); N, the slope of the PK/PD relationship profile; the bacteriostasis, bactericidal and eradication were defined as the net static, 3-log10, and 4-log10 kill effects after 24 h of incubation; NA, not applicable. b Data were acquired from three independent evaluations for ex vivo activity of gamithromycin in rabbit plasma
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us