Table 1 Pharmacokinetic parameters (mean ± SD, n = 9) of gamithromycin in New Zealand rabbits after single intravenous (IV) and subcutaneous (SC) administrations at 6 mg/kg
From: Pharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis
PK parameters | Unit | IV | SC |
|---|---|---|---|
λz | 1/h | 0.03 ± 0.01 | 0.02 ± 0.01 |
T1/2λz | h | 24.5 ± 6.23 | 31.5 ± 5.74 |
Cmax | mg/L | NA | 1.64 ± 0.86 |
Tmax | h | NA | 0.37 ± 0.26 |
AUC0 − 24 h | mg·h/L | 3.94 ± 0.56 | 3.25 ± 0.37 |
AUC0 − t | mg·h/L | 5.26 ± 1.05 | 4.37 ± 0.67 |
AUC0−∞ | mg·h/L | 5.66 ± 0.98 | 4.91 ± 0.60 |
MRTlast | h | 22.3 ± 6.18 | 27.2 ± 7.35 |
Vz | L/kg | 38.8 ± 12.8 | 57.0 ± 13.2 |
Cl | L/kg/h | 1.07 ± 0.15 | NA |
Cl/F | L/kg/h | NA | 1.24 ± 0.15 |
F | % | NA | 86.7 ± 10.7 |