Fig. 2

In vitro PAE and PA-SME values for gamithromycin against P. multocidaCVCC 434. (A) Standard curve constructed by regression of the viable bacterial counts and absorbance (OD_600nm) of P. multocida CVCC 434. The solid points represent the observed data and the line represents the best fitting curves as follows: y = 1.0633 ln(x) + 10.929 (R² = 0.9453). (B-C) The PAEs (B) were measured after initial exposure to gamithromycin at 1× and 4× MIC against P. multocida CVCC 434; The PA-SME (C) was determined after an initial exposure to gamithromycin at 4×MIC. The horizontal bars represent the time required for viable counts of bacteria to increase by 1.0 log₁₀ cfu/mL in the drug removal (PAE) and sub-MIC phase (PA-SME)