BMC Veterinary Research

Table 1 Effects of different vaccines on IgG, IFN-γ and IL-4 contents in serum of mice at different time points

From: Efficacy of H₂O₂ inactivated bovine virus diarrhoea virus (BVDV) type 1 vaccine in mice

	Group				P-value
Item	NC	H₂O₂	Formaldehyde	SEM	Group	Time	Group × Time
IgG
day0	0.18	0.14	0.18	0.00	< 0.01	< 0.01	< 0.01
day14	0.17^a	0.38^b	0.30^b	0.02
day21	0.18^a	0.50^b	0.40^c	0.01
day28	0.20^a	0.51^b	0.42^c	0.01
day35	0.15^a	0.55^b	0.43^b	0.01
day42	0.17^a	0.67^b	0.51^c	0.01
day49	0.20^a	0.66^b	0.55^c	0.01
day56	0.18^a	0.65^b	0.59^b	0.01
day63	0.18^a	0.49^b	0.46^b	0.02
day70	0.14^a	0.26^b	0.28^b	0.01
IFN-γ
day0	81.04	84.69	74.69	11.30	0.142	0.036	< 0.01
day14	78.17	119.13	88.06	12.24
day28	62.50	123.16	115.19	11.50
day42	80.32	96.24	125.52	10.62
day56	91.73	98.24	85.22	13.17
day70	80.83	65.12	87.07	8.37
IL-4
day0	60.19	55.43	48.35	9.35	< 0.01	< 0.01	< 0.01
day14	53.50^a	114.00b	124.98^bc	13.39
day28	49.32^a	143.80^b	130.87^bc	13.33
day42	57.35^a	116.44^b	92.39^bc	7.47
day56	58.64	69.96	84.49	10.46
day70	65.63	50.96	62.51	8.44

^a,^b,c Means in the same row with different superscripts are significantly different (P ≤ 0.05). Ifn-γ and IL-4 concentration units are pg/ml

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