Fig. 4

Functional analysis of the overlapping genes between the differentially expressed (DE) mRNAs and the potential target genes of DE lncRNAs in avian pathogenic E. coli infected macrophages (APEC) vs. non-infected macrophages (Control). A. The potential target genes of the identified DE lncRNAs. B. Venn diagram of the number of the overlapping genes between the DE mRNAs and the target genes of DE lncRNAs in APEC vs. Control. C. GO analysis of the overlapping genes between the DE mRNAs and the target genes of DE lncRNAs in APEC vs. Control. a, P2RY8; b, GPR35L; c, GPR35; d, GPR65; e, LOC112532977; f, LFNG; g, GALNT11; h, MFNG; i, SLC12A4; j, ADD1; k, SLC12A9; l, JUP; m, PRKCB; n, BRCA1; o, RHOB; p, VEGFA; q,CD86; r, TNFSF15; s, LY86; t, TNFSF8; u, TLR7; v, CTSV; w, CD244; x, RASGEF1A; y, RASGEF1B; z, DOCK8; aa, LOC429518; ab, RND2; ac, CHRNA1; ad, PHLPP1; ae, LOC428967; af, LRRK1; ag, FAM13A; ah, AFDN; ai, RASSF5; aj, IL1RAPL2; ak, RHPN1; al, TCP11L1; am, SRGAP2; an, PLPP1; ao, BCL2A1; ap, IKBKE; A, positive regulation of Rho protein signal transduction; B, regulation of Notch signaling pathway; C, cell volume homeostasis; D, positive regulation of angiogenesis; E, immune response; F, small GTPase mediated signal transduction; G, signal transduction; H, intrinsic apoptotic signaling pathway in response to DNA damage. D. KEGG analysis of the overlapping genes between the DE mRNAs and the target genes of DE lncRNAs in APEC vs. Control. E. Cytoscape visualizing of the overlapping DE genes and their corresponding lncRNAs that enriched in the immune related pathway