Fig. 5

The long- term effect of an intrauterine device (IUD) inserted on day 0 (A,B, C) and IUD inserted on days 5–6 post-ovulation (D, E, F) on transcripts of prostaglandin-endoperoxide synthase-2 (PTGS2) (A, D), prostaglandin E₂ synthases (PTGES) (B, E), and prostaglandin F_2α synthases (PTGFS) (C, F), in equine endometrial biopsies collected within the time intervals during the estrous cycle: days 10 -12, 16- 18, 20—21 from IUD mares compared with the control biopsies (collected on the same days of the estrous cycle before IUD insertion). Asterisks indicate significant differences (^*P < 0.05; ^**P < 0.01; ^***P < 0.001) between endometrial biopsies collected before and after IUD insertion at the same time point. Superscript letters indicate significant differences between the control group (before IUD ^a,b) across the time points (days of the estrous cycle) or between IUD mare group (after IUD.^x,y,z) across the time points (days of the estrous cycle)