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Table 1 Effects of FPN exposure on body weight, spleen index, and cellularity of splenocytes

From: Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice

 

NA

VH

Fipronil (mg/kg)

1

5

10

Body Weight

     

Day 1

21.39 ± 0.25

21.56 ± 017

21.24 ± 0.21

21.5 ± 0.21

21.68 ± 0.18

Day 16

23.68 ± 0.31

23.22 ± 0.24

22.46 ± 0.18

22.31 ± 0.23*

21.74 ± 0.19*

Spleen index

3.888 ± 0.07

4.124 ± 0.05

4.205 ± 0.1

4.211 ± 0.96

4.577 ± 0.26

Spleen Cellularity (%)

     

CD4+

24.03 ± 0.43

21.9 ± 0.66

17.52 ± 1.63

18.22 ± 1.7

21.21 ± 0.51

CD8+

13.28 ± 0.61

14.23 ± 0.57

13.61 ± 0.7

13.67 ± 0.74

13.22 ± 0.78

B220+

50.94 ± 1.07

51.78 ± 1.4

52.75 ± 1.41

51.87 ± 1.13

49.76 ± 1.33

CD11b+

1.92 ± 0.34

1.49 ± 0.25

1.68 ± 0.3

1.5 ± 0.23

1.72 ± 0.32

Gr1+

1.18 ± 0.25

0.99 ± 0.19

1.03 ± 0.22

0.98 ± 0.2

1.03 ± 0.19

CD11b+/Gr1+

1.77 ± 0.14

2.29 ± 0.22

2.19 ± 0.21

2.34 ± 0.24

2.4 ± 0.24

  1. a Spleen index was calculated as the spleen weight (mg) per body weight (g). Data was expressed as mean ± SEM of 20 mice pooled from four independent experiments
  2. b Splenocytes were prepared as described in the Materials and Methods section. The percentage of CD4+, CD8+, B220+, CD11b+, and Gr1+ cells was determined by flow cytometry. Data was expressed as mean ± SEM pooled from four independent experiments (n = 20). *p < 0.05 as compared with the VH group
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BMC Veterinary Research

ISSN: 1746-6148

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