Test substance (mg/kg) | Log number trypanosomes/ml | |||||||
---|---|---|---|---|---|---|---|---|
Day 0 | Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | Day 12 | Day 14 | |
1% DMSO | 7.26 ± 0.06 | 7.74 ± 0.14 | 8.28 ± 0.07 | 8.58 ± 0.07 | 8.64 ± 0.06 | 8.70 ± 0.0 | 8.82 ± 0.07 | 8.94 ± 0.06 |
DA 28.00 | 7.32 ± 0.07 | 2.16 ± 1.32a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 1.08 ± 1.08a3 | 2.16 ± 1.32a3 |
RM-M 100 | 7.26 ± 0.06 | 6.90 ± 0.09b3,(i−k)3 | 6.6 ± 0.00a3,b3,(h–k)3 | 6.18 ± 0.20a3,b3,(h–k)3 | 4.86 ± 1.23b1,(i−k)1 | 6.30 ± 0.09a3,b3,(h–k)3 | 6.48 ± 0.07a3, b3,(i−k)3 | 6.78 ± 0.07a3,b3,(i−k)3 |
RM-M 200 | 7.32 ± 0.07 | 6.78 ± 0.12b3,(i−k)3 | 6.48 ± 0.07a3,b3,(h–k)3 | 5.88 ± 0.20a3,b3,(h–k)3 | 4.44 ± 1.11 | 6.12 ± 0.2a3,b3,(h–k)3 | 6.42 ± 0.07a3,b3,(i−k)3 | 6.60 ± 0.00a3,b3,(i−k)3 |
RM-M 400 | 7.26 ± 0.05 | 6.72 ± 0.07b3,(i−k)3 | 6.18 ± 0.07a3,b3,(h–k)3 | 5.52 ± 0.12a3,b3,(h–k)3 | 2.16 ± 1.32a3 | 3.24 ± 1.32a3,b3,(h–k)3 | 4.32 ± 1.08a3 | 5.40 ± 1.13a3 |
RM-H 8.75 | 7.26 ± 0.05 | 6.72 ± 0.07b3,(i−k)3 | 6.18 ± 0.07a3,b3,(h–k)3 | 5.52 ± 0.12a3,b3,(h–k)3 | 2.16 ± 1.32a3 | 3.24 ± 1.32a3,b3,(h–k)3 | 4.32 ± 1.08a3 | 4.50 ± 1.13a3 |
RM-H 17.50 | 7.26 ± 0.05 | 6.72 ± 0.07b3,(i−k)3 | 6.18 ± 0.07a3,b3,(h–k)3 | 5.52 ± 0.12a3,b3,(h–k)3 | 1.08 ± 1.08a3 | 3.16 ± 1.32a3,b3,(h–k)3 | 4.32 ± 1.08a3 | 4.50 ± 1.13a3 |
RM-H 35.00 | 7.26 ± 0.06 | 5.4 ± 0.00b1,(i−k)3 | 2.16 ± 1.32a3,b3,(i−k)3 | 1.08 ± 1.08a3 | 1.08 ± 1.08a3 | 2.24 ± 1.32a3 | 4.32 ± 1.08a3 | 4.50 ± 0.00a3 |
Anemonin 8.75 | 7.32 ± 0.07 | 2.16 ± 1.32a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 |
Anemonin 17.50 | 7.38 ± 0.07 | 2.16 ± 1.32a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.0a3 | 0.00 ± 0.00a3 |
Anemonin 35.00 | 7.38 ± 0.07 | 1.08 ± 1.08a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 | 0.00 ± 0.00a3 |