Table 1 Inhibitors of cell cytoskeleton used in the study
Substance | Form | Therapeutic effect/treatment |
|---|---|---|
Nocodazole | benzimidazole substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group | antineoplastic agent, a tubulin modulator, an antimitotic, and a microtubule-destabilizing agent and an inhibitor of various cancer-related kinases. |
Noscapine | phthalide isoquinoline alkaloid from Papaver somniferum | analgesic, antitussive, disruption of the dynamics of microtubule assembly, the inhibition of mitosis and tumor cell death, noscapine does not affect microtubule polymerization, antiviral activity by inhibition of Mpro protease. |
Paclitaxel | a tetracyclic diterpenoid from the bark of the Taxus brevifolia | a mitotic inhibitor used in cancer chemotherapy, an antineoplastic agent, a microtubule-stabilizing agent, and an antineoplastic agent. |
Latrunculin A | 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety from Latrunculia magnifica | impacts actin polymerization, microfilament organization, and microfilament-mediated processes. |
Cytochalasin D | cell-permeable fungal toxin; from Zygosporium mansonii | potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction. |