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Table 5 Pharmacokinetic parameters of capecitabine in dogs following single oral dose of 750 mg/m\(^2\). AUC values listed to 2 significant figures

From: A pilot study investigating plasma pharmacokinetics and tolerance of oral capecitabine in carcinoma-bearing dogs

Patient

Time to max concentration (h)

Observed max concentration (ng/ml)

Concentration at 10-h post capecitabine administration (ng/ml)

Area under concentration vs. time curve AUC0-last (hng/ml)

Area under concentration vs. time curve AUC0-6 hrs (hng/ml)

Dog 1

0.25

2600

BLLOQ

1000

1000

Dog 2

0.5

2100

0.4

1100

1100

Dog 3

6

220

17.2

890

Dog 4

3

370

BLLOQ

810

790

Dog 5

6

190

3.8

750

Median

3

370

3.8

890

1000

  1. BLLOQ below lower limit of quantification (0.25 ng/ml), hour