Table 3 Rotational thromboelastometry and platelet function analysis closure time (CtPFA) prior to (T0), and at 5 (T5), 60 (T60) and 120 (T120) minutes after administration of mannitol and hypertonic saline (HTS) shown as the percentage of values relative to T0
| Â | Â | Osmotherapeutic solution | Â | |
|---|---|---|---|---|
Variable | Time point | Mannitol (% from baseline) | HTS (% from baseline) | P value |
CtPFA | T5 | 130 (103-171) | 116 (89-151) | 0.31 |
T60 | 109 (95-126) | 112 (89-149) | 1.00 | |
T120 | 100 (93-109) | 91 (87-107) | 0.32 | |
EXTEM® CT | T5 | 92 (51-113) | 91 (60-239) | 0.35 |
T60 | 107 (70-128) | 95 (60-1299 | 0.21 | |
T120 | 113 (40-159) | 98 (48-143) | 0.65 | |
EXTEM® CFT | T5 | 115 (73-246) | 118 (84-216) | 0.98 |
T60 | 111 (62-194) | 113 (83-359) | 0.97 | |
T120 | 115 (80-182) | 109 (70-162) | 0.62 | |
EXTEM® A10 | T5 | 97 (61-122) | 98 (16-112) | 0.44 |
T60 | 103 (86-2014) | 102 (88-260) | 0.68 | |
T120 | 97 (92-127) | 100 (84-215) | 0.37 | |
EXTEM® α-angle | T5 | 98 (65-273) | 96 (20-104) | 0.48 |
T60 | 99 (71-119) | 98 (71-109) | 0.97 | |
T120 | 100 (71-113) | 100 (93-111) | 0.87 | |
EXTEM® MCF | T5 | 97 (70-300) | 97 (28-104) | 0.86 |
T60 | 100 (91-469) | 98 (46-106) | 0.12 | |
T120 | 101 (90-446) | 97 (89-111) | 0.22 | |
FIBTEM® CT | T5 | 100 (70-138) | 86 (56-108) | 0.01 |
T60 | 111 (72-163) | 81 (55-110) | 0.01 | |
T120 | 94 (75-142) | 85 (25-126) | 0.11 | |
FIBTEM® A10 | T5 | 85 (62-167) | 103 (15-167) | 0.05 |
T60 | 114 (82-146) | 100 (33-300) | 0.76 | |
T120 | 106 (81-135) | 100 (64-200) | 0.76 | |
FIBTEM® α-angle | T5 | 101 (80-109) | 106 (97-119) | 0.09 |
T60 | 99 (92-107) | 101 (22 (124) | 0.60 | |
T120 | 100 (93-104) | 96 (83-112) | 0.56 | |
FIBTEM® MCF | T5 | 89 (58-188) | 100 (19-171) | 0.11 |
T60 | 88 (59-104) | 100 (14-143) | 0.07 | |
T120 | 88 (62-188) | 104 (19-143) | 0.60 | |