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Table 4 Interference effects of hemoglobin, bilirubin and lipid (soya bean oil) on CRP measurement performed with the new automated species-specific immunoturbidimetric assay

From: Evaluation of a species-specific C-reactive protein assay for the dog on the ABX Pentra 400 clinical chemistry analyzer

Interferent

CRPcontrol [mg/l] ± SD

CRPtest [mg/l] ± SD

Mean bias [mg/l]

% bias

% bias < TEdes (29.6%)

% bias < TEopt (14.8%)

Hemoglobin 5 g/l

33.7 ± 0.7

34.3 ± 1

0.57

1.7

Yes

Yes

Bilirubin 800 mg/l

34.8 ± 0.6

34.9 ± 1

0.13

0.37

Yes

Yes

Soy bean emulsion 10 g/l

32.7 ± 0.2

34.4 ± 1

1.63

5.0

Yes

Yes

  1. Test samples (CRPtest) with a mean CRP value of 35.5 mg/l spiked with the interfering substances were measured in triplicates and compared to control samples (CRPcontrol) spiked with equal amounts of the diluent used in the test sample. %Bias for the interfering substance was considered acceptable when it was < desired total allowable error (TEdes) and excellent when it was < optimal total allowable error (TEopt) reported previously [32].
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BMC Veterinary Research

ISSN: 1746-6148

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