Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

Table 5 Parameters of PK/PD modeling based on ex vivo serum data after p.o. administration of sarafloxacin in muscovy ducks (n = 12)

Parameter	Unit	E. coli O78
Log E ₀	CFU/mL	3.58 ± 0.27
Log E ₀ − Log E _max	CFU/mL	8.31 ± 0.28
Slope(N)	—	3.42 ± 0.15
AUC_{0-24 h}/MIC for bacteriostatic action	h	25.4 ± 1.68
AUC_{0-24 h}/MIC EC₅₀	h	27.5 ± 1.86
AUC_{0-24 h}/MIC for bactericidal action	h	40.6 ± 2.46
AUC_{0-24 h}/MIC for bacterial eradication	h	94.5 ± 7.70

E ₀: difference in bacterial count in control sample between time 0 and 24 h; E _max: difference in bacterial count in sample containing sarafloxacin between time 0 and 24 h, when limit of detection is reached; N: the Hill coefficient; AUC_{0-24 h}/MIC EC₅₀: AUC_{0-24 h}/MIC of drug producing 50% of the maximum antibacterial effect

ISSN: 1746-6148