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Table 4 Decrease in monthly seizure frequency, completer population

From: Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy

    

95% Confidence Interval

 

% of animals with

Variable

Cohort

N

%Decrease

LCL

UCL

p-value

any reduction

>50% reduction

MSF

A

5

73.42

−20.92

94.16

0.072

80.0

80.0

B

9

37.12

−2.43

61.36

0.059

88.9

33.3

C

5

43.56

−14.11

72.06

0.087

80.0

40.0

A + B

14

53.74

20.31

73.15

0.009

85.7

50.0

A + B + C

19

51.28

26.58

67.63

0.002

84.2

47.4

MCD

A

5

59.75

−78.25

90.92

0.165

  

B

9

25.55

−27.00

56.35

0.239

  

C

5

−20.92

−262.19

59.67

0.656

  

A + B

14

40.25

−1.21

64.73

0.055

  

A + B + C

19

28.04

−12.98

54.21

0.143

  
  1. MSF = (Number of Seizures/Number of days) x 28 days. MCD = (Number of Cluster days/Number of days) x 28 days. Significant %Decrease (p < 0.05) is bolded. In addition, the paired t-test was applied to the corresponding log-transformed data values separately for each cohort and the two combinations of cohorts (i.e., cohort A + B and all 3 cohorts combined). The displayed p-value is derived from this paired t-test. The fraction of animals showing any reduction and >50% reduction of MSF (“Responder rate”) is given.
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BMC Veterinary Research

ISSN: 1746-6148

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