Table 1 Pharmacokinetic parameters (mean ± S.D.) of ceftiofur in lactating goats after IV and SC administration at a dose of 2.2 mg/kg bodyweight, and after SC-LA administration at a dose of 6.6 mg/kg bodyweight (n = 6)
Treatment | |||
|---|---|---|---|
Parameters | Intravenous | SC | SC-LA |
λ z (1/h) | 0.16 ± 0.07 | 0.14 ± 0.06 | 0.02 ± 0.01 a, b |
t½λz 1 (h) | 4.21 | 5.10 | 41.12a, b |
Vss (L/kg) | 0.18 ± 0.05 | -- | -- |
Vz (L/kg) | 0.31 ± 0.14 | -- | -- |
AUC0–24 (μg · h/mL) | 45.51 ± 6.80 | 38.17 ± 6.97 | 85.13 ± 7.53 a |
AUC0-∞ (μg · h/mL) | 47.06 ± 6.84 | 39.88 ± 6.26 | 117.12 ± 11.54 a |
MRT (h) | 4.27 ± 0.98 | 6.29 ± 0.35a | 25.11 ± 4.35 a, b |
Cl (L/h · kg) | 0.04 ± 0.01 | -- | -- |
MAT (h) | -- | 2.02 ± 1.09 | 20.83 ± 5.13 b |
Ka (1/h) | -- | 0.53 ± 0.49 | 0.03 ± 0.01 b |
Cmax (μg/L) | -- | 6.25 ± 0.85 | 7.77 ± 1.26 |
Tmax (h) | -- | 0.91 ± 0.20 | 4.66 ± 2.05 b |
F (%) | -- | 85.16 ± 10.24 | 84.43 ± 7.40 |