Table 2 Details of scrapie-affected goats that provided milk and/or had milk tested for PrPsc
From: Evidence of scrapie transmission to sheep via goat milk
Donor | Genotype codon 142 | Clinical status | Post-mortem TSE status (LRS tissue & brain)b | CAEV status | PrPsc in mammary gland | PMCA positive result in milk/ number of tests (days of lactation) | Weekly somatic cell count in milk [×103 cells/ ml] (median) |
|---|---|---|---|---|---|---|---|
Milk transmission study | |||||||
G1472 | II | – | 2/10 & N | – | absent | 0/2 (1, 10, 19, 29) | 1013, 1922, 993, 1514 (1003) |
BIIa | II | + | 7/10 & P | – | absent | 0/2 (5, 35); 1/3 (20), 0/3 (51) | 878, 3707, 1152, 949, 3469, 1192 (1172) |
G1143 | II | ± | 9/10 & N | + | present | 0/2 (1, 16, 30, 45) | 86, 155, 163, 97, 262, 136 (145.5) |
G1427a | II | – | 10/10 & N | + | present | 0/2 (6, 22, 47, 66) | 956, 2445, 640, 439, 171, 415, 419, 219, 388, 551 (429) |
G1465 | IM | ± | 1/10 & N | + | absent | 0/2 (1, 10, 18, 29) | 413, 990, 2140, 978 (984) |
G1415 | IM | ± | 8/10 & P | – | absent | 0/2 (1, 20, 39, 59) | 1591, 279, 405, 439, 336, 431, 627, 369 (418) |
G1383 | IM | ± | 9/10 & P | – | absent | 0/2 (1, 21, 42, 61) | 4708, 312, 269, 219, 132, 148, 92, 107 (183.5) |
BIM | IM | ± | 10/10 & P | – | absent | 0/2 (1, 21); 1/3 (43); 0/3 (61) | 2556, 271, 459, 6133, 267, 84, 347, 225 (309) |
PrPsc detection only by sPMCA | |||||||
G1376 | II | – | 0/10 & N | – | absent | 0/2 (1, 10, 29); 0/3 (18) | 853, 3420, 205, 3109 (1981) |
G1136 | IM | – | 0/10 & N | – | absent | 0/2 (1, 9, 18, 29) | 354, 565, 378, 531 (454.5) |
G1382 | IM | – | 0/10 & N | + | absent | 0/2 (1, 19); 0/3 (10, 29) | 135, 4388, 3835, 7007 (4112) |
G1454 | IM | ± | 0/10 & N | – | absent | 0/2 (1, 10, 19, 29) | 11, 8373, 469, 2808 (1639) |
G1122 | MM | – | 0/10 & N | – | absent | 0/2 (1, 37, 55); 0/3 (18) | 238, 3646, 3586, >10000, >10000, 244, 215, 331 (1959) |
G1115 | MM | ± | 0/10 & N | – | absent | 0/2 (1, 19, 37, 56) | 48, 325, 535, 322, 300, 108, 198, 340 (311) |