In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin

Table 3 Pharmacokinetics and pharmacodynamics variables in plasma for two antimicrobial agents against R. anatipestifer isolates

Antimicrobial	Dosage regimen (mg/kg)	C_max (μg/mL)	AUC_24h (μg h/mL)	C_max/MIC₉₀	C_max/MPC₉₀	AUC₂₄/MIC₉₀ (h)	AUC₂₄/MPC₉₀ (h)	T > MIC₉₀ (h)	T > MPC₉₀ (h)	%T _MSW
Cefquinome^a	5, IM	9.38	23.78	18.76	0.15	47.56	0.37	~7.6	0	31.67
Florfenicol^b	30, IM	3.24	36.42	1.62	0.10	18.21	1.14	~5.2	0	21.67

C _max serum maximum concentration, AUC _24h area under curve over a 24 h time period, MIC minimum inhibitory concentration, MPC mutant prevention concentration, T _MSW time inside the mutant selection window, IM intramuscularly
^a based on data as published by Yuan et al
^b based on data as published by EL-Banna

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