Table 4 Relative fold changes in gene expression in HD11 cells infected with different MOI of vvIBDV strain UPM0081 at 6, 24 and 48 hpi

IL-1β

<2

2.33 ± 0.19^a

5.53 ± 0.37^b

6.74 ± 1.78^b

<2

2.92 ± 0.65^a

CCL4

2.47 ± 1.03^a,b

4.07 ± 0.64^a,b

3.89 ± 0.85^b

5.07 ± 1.17^a

2.69 ± 0.78^a

3.29 ± 0.90^a

CXCLi1

3.39 ± 0.45^a

4.34 ± 0.54^b

1.99 ± 0.35^c

2.32 ± 0.49^c

<2

<2

CXCLi2

2.24 ± 0.41^a

2.44 ± 0.27^a

6.44 ± 0.75^b

9.02 ± 0.45^c

3.84 ± 0.40^d

4.40 ± 1.14^d

IL-12α

2.10 ± 0.39^a

3.32 ± 0.78^b

3.43 ± 0.31^b

4.32 ± 1.2^b

<2

<2

IL-18

<2

3.05 ± 0.53^a

2.46 ± 0.23^b

3.34 ± 0.50^b

<2

<2

IL-10

-2.44 ± 0.23^a

-4.17 ± 0.10^b

-2.00 ± 0.33^c

-2.86 ± 0.36^d

<2

-2.22 ± 0.13^a,c

TLR2-1

<2

<2

<2

<2

<2

<2

TLR3

<2

2.65 ± 0.37^a,b

2.00 ± 0.90^a

4.90 ± 0.44^c

3.22 ± 0.14^b

5.22 ± 0.45^c

TLR4

<2

<2

<2

<2

<2

<2

TLR5

<2

<2

<2

<2

<2

<2

TLR7

<2

<2

<2

<2

<2

<2

IL-15

<2

<2

<2

<2

<2

<2

IL-16

<2

<2

<2

-2.13 ± 0.15

<2

<2

iNOS

3.67 ± 0.53^a

4.73 ± 0.16^b,c

3.52 ± 1.1^a,b

7.51 ± 0.73^d

5.57 ± 0.61^c

5.68 ± 0.44^c

MHCI

<2

<2

<2

-2.22 ± 0.22^a

2.59 ± 1.18^b

3.13 ± 1.40^b

MHCII

-2.33 ± 0.08^a

-3.13 ± 0.08^b

<2

-4.55 ± 0.14^c

<2

-5.26 ± 0.09^d

TGF-β3

<2

<2

<2

<2

<2

<2