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Table 3 Under-represented cellular pathways in canine mammary cancer

From: Gene expression profiles in canine mammary carcinomas of various grades of malignancy

Cellular pathways

1vs 2

1vs 3

2vs 3

5HT1 type receptor mediated signaling pathway

 

X

X

Alzheimer disease-amyloid secretase pathway

X

X

 

Alzheimer disease-presenilin pathway

X

X

 

Angiogenesis

X

X

 

Apoptosis signaling pathway

X

X

 

B cell activation

X

X

 

Beta1 adrenergic receptor signaling pathway

 

X

X

Beta2 adrenergic receptor signaling pathway

 

X

X

Cadherin signaling pathway

X

X

 

EGF receptor signaling pathway

X

X

 

Endothelin signaling pathway

X

X

X

GABA-B_receptor_II_signaling

 

X

X

Glycolysis

X

X

 

Hedgehog signaling pathway

 

X

X

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

 

X

X

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

X

 

X

Histamine H2 receptor mediated signaling pathway

 

X

X

Huntington disease

X

X

 

Hypoxia response via HIF activation

 

X

X

Inflammation mediated by chemokine and cytokine signaling pathway

X

X

 

Metabotropic glutamate receptor group II pathway

 

X

X

Metabotropic glutamate receptor group III pathway

 

X

X

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

 

X

X

Oxidative stress response

X

X

X

PDGF signaling pathway

X

X

 

Parkinson disease

X

X

 

T cell activation

X

X

 

Thyrotropin-releasing hormone receptor signaling pathway

X

  

Transcription regulation by bZIP transcription factor

 

X

X

Wnt signaling pathway

X

X

 

p53 pathway by glucose deprivation

X

X

 
  1. Cellular pathways in which are involved significantly down-regulated genes in the examined tumour groups. The analysis was conducted using PANTHER Database (http://www.pantherdb.org). The pathway activity in the tumour group 1 vs 2, 1 vs 3 and 2 vs 3 is marked as X.