Parameter | Units | PO Serum | PO ISF |
---|
C
max
| μg/ml | 2.77±0.63# | 2.71±0.8# |
AUC
24
| h*μg/ml | 24.21±5.09 | 35.19±8.39 |
AUCi
nf
| h*μg/ml | 26.76±6.27# | 43.38±17.54# |
T
max
| h | 2±1.1* | 6±3.35* |
T
1/2
| h | 6.31±1.74# | 8.35±3.5# |
T
24
| h | 24±0 | 24±0 |
λ
z
| /h | 0.12±0.03 | 0.09±0.03 |
MRT
last
| h | 7.16±1.31 | 10.16±1.83 |
MRT
inf
| h | 9.58±3.04 | 14.6±6.41 |
- Cmax maximum concentration; AUC24 area under the curve from time 0 to 24 hours; MRTlast mean residence time; λz first order rate constant of terminal portion of the curve; T1/2 half-life; Tmax time to maximal concentration; T 24 time of final measurement; AUCinf area under the curve from 0 extrapolated to infinity; MRTinf mean residence time from time 0 extrapolated to infinity for non-infusion models; * statistical different (p ≤ 0,05); # no statistical difference (p ≤ 0,05).