Skip to main content

Table 1 Pharmacokinetic parameters (mean ± SD) of cimicoxib administered by the IV route at 2 mg/kg to 12 dogs

From: Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

Parameters

Extensive metabolizers (n = 8)

Poor metabolizers (n = 4)

AUC (h.μg/L)

7202 ± 1814*

19151 ± 3149*

V (L/kg)

1.12 ± 0.203

0.89 ± 0.133

HL (h)

2.72 ± 0.858*

5.63 ± 0.727*

CL (L/h/kg)

0.31 ± 0.118*

0.11 ± 0.022*

  1. Data were analysed using non-compartmental approach; AUC: Area under the curve; V: Volume of distribution; HL: Plasma half- life; Cl: plasma clearance.
  2. *Difference were significant between the two groups p < 0.001 for HL and AUC and p < 0.01 for the CL.
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us