BMC Veterinary Research

Table 5 PK parameters of ciprofloxacin in grass carp (n = 5)

From: Integrated pharmacokinetics/pharmacodynamics parameters-based dosing guidelines of enrofloxacin in grass carp Ctenopharyngodon idella to minimize selection of drug resistance

Tissues Parameter	Dose
Tissues Parameter	10 mg/kg				20 mg/kg				30 mg/kg
	Serum	Liver	Muscle	Kidney	Serum	Liver	Muscle	Kidney	Serum	Liver	Muscle	Kidney
A(μg/mL)	0.104	0.172	0.048	0.118	0.169	0.435	0.185	0.21	0.203	0.687	0.254	0.453
A(/h)	0.01	0.008	0.001	0.011	0.009	0.008	0.003	0.012	0.007	0.007	0.005	0.015
Ka(/h)	0.078	0.249	0.171	0.202	0.268	0.222	0.171	0.214	0.248	0.217	0.222	0.211
Kel(/h)	0.031	0.027	0.016	0.019	0.02	0.028	0.012	0.022	0.019	0.025	0.012	0.023
T_1/2α(h)	70.300	54.558	126.553	46.273	74.727	74.283	129.297	57.892	92.733	98.544	140.684	63.202
Tmax(h)	6.000	1.000	48.000	6.000	1.000	0.500	10.000	2.000	0.500	0.500	4.000	1.000
Cmax(μg/mL)	0.187	0.759	0.233	0.188	0.225	1.219	0.276	0.348	0.254	1.480	0.329	0.386
MRT_0-t(h)	61.453	61.61	60.652	59.982	64.912	62.200	71.581	63.192	69.093	67.674	73.703	64.946
AUC(μg/mL·h)	8.392	17.09	2.704	7.633	13.516	29.941	21.380	12.166	17.665	55.732	26.675	18.329
CLs(L/kg·h)	0.920	0.429	17.893	0.913	1.078	0.214	0.272	0.572	1.072	0.102	0.210	0.331

A(μg/mL), Intercept of the linear equation on log transformed data; α(/h), Distribution rate constant; Ka(/h), Absorption rate constant; Kel(/h), elimination rate constant from the central compartment; T_1/2α(h), Half-life of distribution; Tmax(h), Time required to reach Cmax in the interval; Cmax(μg/mL), Maximum concentration in the interval; MRT_0-t(h), Mean residue time of drug in body from zero to 168h; AUC(μg/mL·h), Area under the drug concentration-time curve from the time zero to last time point; CLs(L/kg·h), total body clearance.

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ISSN: 1746-6148

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