Table 9 Semiquantitative scoring systems for systemic disease models

Small intestine: villous blunting, crypt regeneration/apoptosis/loss, enterocyte loss, infiltration (each 0–4); Colon: crypt regeneration, colonocyte vacuolization, crypt apoptosis/destruction, infiltration (each 0–4)

389

Small/large bowel: villous blunting, crypt regeneration/apoptosis/loss, luminal sloughing, infiltration, mucosal ulceration, epithelial/vacuolization (each 0–4), liver: portal infiltration, bile duct apoptosis/sloughing, parenchymal apoptosis/abscesses/mitoses, steatosis, cholestasis (each 0–4)

170

Skin: epidermal damage, dermal collagen density, dermal infiltration, subcutaneous fat loss, hair follicle loss (each 0–2), intestine: crypt apoptosis, inflammation(each 0–4), liver: bile duct injury (0–4)

50

Alveolar membrane thickening, congestion, edema, intraalveolar hemorrhage, interstitial, intraalveolar infiltration (each 0–3)

36

Intestine: % injury (number of edematous villi x 0,5 + number of villi with epithelial damage x 1), lung: number of neutrophils in 10 fields

2

Lung: atelectasis, hemorrhage, edema, congestion, inflammation, hyp-eraeration (each 0–3); ileal mucosal damage, (0–5), liver: congestion, necrosis, vacuolization (each 0–3), Kidney: epithelial swelling, tubular dilation, necrosis, edema, microthrombosis (each 0–3)

2

Complete assessment of all lymphoid organs (each 0–4)

50

Tubulitis, arteritis, mononuclear cell interstitial infiltrates, glomerulitis, interstitial fibrosis, tubular atrophy, glomerulopathy, mesangial matrix increase, vascular fibrous intimal thickening, arteriolar hyaline thickening (each 0–3)

1.727

Infiltration, myocyte damage (0–4)

1401

Infiltration, myocyte damage (0–3)

365

Inflammation (0–4), lymphocyte infiltration (0–1), bronchiolitis obliterans (0–4), Vascular rejection (0–1), vasculitis (0–1)

362

Acanthosis, ulceration, necrosis, inflammation, granulation tissue (0–5)

1