Figure 2
From: O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
Down-regulated MGMT protein expression in equine sarcoidfibroblasts. Immunofluorescence-mediated detection of MGMT protein in normal equine fibroblasts and sarcoid fibroblasts, assessed by confocal microscopy. A) Normal fibroblasts cell line E-Derm shows cytoplasmic staining for MGMT. Nuclei of mitotic cells express MGMT (insert).x120. B) Fully transformed fibroblasts EqSO1a show a faint cytoplasmic staining. x120. C) Fully transformed fibroblasts EqSO4b show a very faint cytoplasmic staining. x120.