Fire ignition during laser surgery in pet rodents
© Collarile et al.; licensee BioMed Central Ltd. 2012
Received: 18 June 2012
Accepted: 23 September 2012
Published: 26 September 2012
Laser surgery is an attractive alternative to other means of section device in terms of tissue inflammation and interaction, which has been extensively used in human and veterinary medicine. Although accidental ignition during laser surgeries is sporadically reported in human medical literature, to the authors’ knowledge this is the first report regarding laser-dependent fire ignition during surgery in veterinary medicine.
Two rodents, a 13-month old, 27-gram, male pet mouse (Mus musculus) and a 1-year old, female Russian hamster (Phodopus sungorus), underwent surgical removal of masses with diode laser. During the surgical procedures fires ignited from the face masks. The mouse presented severe burns on the head and both forelimbs, it was hospitalized and approximately 2 months after surgery burns were resolved. The hamster presented severe burns on the face and the proximal regions of the body. At 72 hours from the accident the hamster was euthanized.
The present report suggests that fire ignition is a potential life-threatening complication of laser surgery in non-intubated rodents maintained under volatile anesthesia. High oxygen concentrations, the presence of combustible, and the narrowness of the surgical field with the face mask during laser surgery on rodents are risk factors for fire ignition.
KeywordsLaser Rodent Pet Surgery Fire Ignition Face mask Burn
Laser surgery is an attractive alternative to other means of section device in terms of tissue inflammation and interaction , which has been extensively used in human [2–5] and veterinary medicine [6–8].
In laboratory rodents, laser surgery promoted rapid postoperative healing  and allowed a significant reduction in tumor recurrence and mortality rates . Several experienced surgeons propose the use of laser surgery in pet rodents [11, 12].
Indeed, several articles on the complications associated with laser surgery have been published [13–15]. Among other complications (e.g. accidental burns, edema of mucus membranes and airway obstruction in larynx surgery), ignition is probably the most dangerous one [16, 17].
Although some authors reported fire ignition as a risk associated with laser procedures , to the authors’ knowledge specific reports of laser-dependent fire ignition in veterinary medicine are lacking. The objective of this report is to describe two cases of fire ignition observed during laser surgery in non-intubated rodents under volatile anesthesia.
Case 1: Mouse
Case 2: Hamster
The present report underline that ignition is a potential life-threatening complication of laser surgery in non-intubated rodents under volatile anesthesia. Although accidental ignition during laser surgeries is sporadically reported in human medical literature [17, 20–23], to the author’s best knowledge this is the first report in which laser-secondary ignition is described in veterinary literature.
For any fire to start, three elements must be present: heat or an ignition source, fuel and an oxidizer. The three elements constitute the so-called “fire triad” or “fire triangle” [24, 25]. An oxidizer is a substance that gains electrons in a red-ox chemical reaction. The most common oxidizers in the operating room are oxygen and nitrous oxide . The most common ignition sources cited in operating room fires seem to be the electrosurgical unit , although also lasers are another common ignition source. As previously stated heat can replace the ignition source: the heat produced by the fiberoptic light source was responsible of operating room fire . Fuels can be from alcohol based solutions, to any cloth-containing or paper-containing materials on or around the patient, including abdominal gasses .
Indeed, an oxygen-rich atmosphere, flammable materials, and ignition sources are virtually ubiquitous in the modern-day operating room .
In human medical literature, laser-secondary ignitions are mainly reported during upper airways surgeries , especially laryngeal [17, 22, 23] and tracheal  surgeries. On 20,000 laryngeal laser-surgical procedures, Sesterhenn and colleagues  reported 15 cases (0.075%) of tube fires. The mechanism of combustion is the initial penetration of the endotracheal tube by the laser and then the ignition of the tube. This is facilitated by the heat produced by the laser, the flow of oxygen, inflammable anesthetic agents or combustible materials [16, 23, 28]. We suppose that in the present cases the elements composing the “fire triangle” (oxidizer/inflammable substance/ignition source)  were: 100 per cent oxygen, sevoflurane or isoflurane and diode laser at 3–3.5 W continuous pulsation, respectively. Decrease or removal of any element of the fire triangle could have prevented fire ignition.
In a recent study 15 rats underwent resection of a 3-mm transverse area of the anterior tongue by use of a carbon dioxide laser . The rats in the study were not exposed to inhalant anesthesia or to oxygen. It is not unexpected that no fire ignition consequent to the procedure was reported in that study. This finding corroborates the role that oxygen and inhalant gasses play in fire ignition during laser surgery.
In the present work we presented two cases in which the oxygen was administered at 100 per cent concentration. Oxygen concentrations of 50 and 75 per cent did not alter the time to ignition of surgical patties exposed to laser beam. Indeed the time to ignition felt significantly when the oxygen concentration was further increased to 100 per cent . A previous study already demonstrated that surgical drapes present a lower time to ignition when exposed to higher oxygen concentration . Considering such findings, ventilation with 100 per cent oxygen should be avoided when laser surgeries are performed under face mask ventilation. An alternative to 100 per cent oxygen ventilation may be the ventilation with a lower oxygen concentration (e.g. 30-60-80 per cent), as it has been suggested in human medicine to prevent atelectasis [32–34]. Although lower oxygen concentrations may decrease the risk of fire ignition, specific reports investigating its impact on rodent surgery outcome are necessary before its application in clinical practice.
Intubation in rodents is, in most cases, not easily performed; therefore anesthesia is often maintained with a tight-fitting face mask connected to the breathing system [35, 36]. As suggested by Dave and Mahaffey  “The use of face masks and nasal cannulae should be avoided as there is always some leakage around these devices”. In the present reports the face mask employed (Figure 1) did not prevent leakage of oxygen and anesthetic gasses. Face masks similar to those employed by the authors are often used during surgeries of small exotic animals [35, 38, 39]. The use of tight-fitting face masks providing a hermetical seal seems necessary during laser surgery under volatile anesthesia in rodents. Anesthetic gas leakage from standard rodent non-rebreathing circuits has been demonstrated . The use of modified face masks significantly reduced the volume of gas leakage. The masks were modified by addition of a latex diaphragm to the conical mask attached to the Mapleson E circuit . Nevertheless, before laser can be safely employed on non-intubated animals under volatile anesthesia, specific trials focusing on the real efficacy of face masks in preventing gas leakage are necessary.
In the two cases described topical scrub was not performed with alcohol due to its intrinsic inflammable properties. Unfortunately, also most commercial chlorhexidine solutions contain alcohol, and their flammability is in direct proportion to their alcohol concentration . Although some case reports identifying alcohol-based skin preparations as a fuel source in surgical fires have been published in human medical literature [41–43], a recent study was unable to demonstrate flammability of isopropyl alcohol exposed to electrofulguration in experimental settings . Conversely, when materials in the study were poured with chlorhexidine gluconate under saturated and damp conditions produced a spark and associated mild to moderate char . Only water-based prep solutions such as betadine contain no alcohol and, therefore, can be considered truly nonflammable . It should be also mentioned that the use of alcohol in surgeries of rodents is discouraged, as it could promote hypothermia [11, 45].
Although in human medical literature most cases of fire ignition seems to be managed without vital damage of the patient [22, 46], in the present cases, catastrophic, life-threatening injuries were suffered from both animal patients.
Fire ignition is a potential complication during laser surgeries in rodents due to the narrowness of surgical field with oxygen outflow and anesthetic gasses. Besides paying appropriate care when specific regions (e.g. airways and oral cavity [7, 8]) are target of laser surgery, the surgeon should always be aware of fire ignition when laser surgeries are performed on non-intubated animals under volatile anesthesia.
Consent was obtained from the owners of the animals for publication of this case report and any accompanying images.
- Dunié-Mérigot A, Bouvy B, Poncet C: Comparative use of CO2 laser, diode laser and monopolar electrocautery for resection of the soft palate in dogs with brachycephalic airway obstructive syndrome. Vet Rec. 2010, 167: 700-704. 10.1136/vr.c5107.View ArticlePubMedGoogle Scholar
- Hall RR, Hill DW, Beach AD: A carbon dioxide surgical laser. Ann R Coll Surg Engl. 1971, 48: 181-188.PubMed CentralPubMedGoogle Scholar
- Bellina JH: The use of the carbon dioxide laser in the management of condyloma acuminatum with eight-year follow-up. Am J Obstet Gynecol. 1983, 147: 375-378.PubMedGoogle Scholar
- Rau BK, Harikrishnan KM, Krishna S: Endoscopic laser ablation of duodenal carcinoids: a new treatment modality. J Clin Laser Med Surg. 1995, 13: 37-38.PubMedGoogle Scholar
- Puthussery FJ, Shekar K, Gulati A, Downie IP: Use of carbon dioxide laser in lingual frenectomy. Br J Oral Maxillofac Surg. 2011, 49: 580-581. 10.1016/j.bjoms.2010.07.010.View ArticlePubMedGoogle Scholar
- Mison MB, Steficek B, Lavagnino M, Teunissen BD, Hauptman JG, Walshaw R: Comparison of the effects of the CO2 surgical laser and conventional surgical techniques on healing and wound tensile strength of skin flaps in the dog. Vet Surg. 2003, 32: 153-160.PubMedGoogle Scholar
- Kovács K, Jakab C, Szász AM: Laser-assisted removal of a feline eosinophilic granuloma from the back of the tongue. Acta Vet Hung. 2009, 57: 417-426. 10.1556/AVet.57.2009.3.8.View ArticlePubMedGoogle Scholar
- Taney K, Smith MM: Resection of mast cell tumor of the lip in a dog. J Vet Dent. 2009, 26: 28-34.PubMedGoogle Scholar
- Wang Z, Devaiah AK, Feng L, Dasai U, Shapira G, Weisberg O, Torres DS, Shapshay SM: Fiber-guided CO2 laser surgery in an animal model. Photomed Laser Surg. 2006, 24: 646-650. 10.1089/pho.2006.24.646.View ArticlePubMedGoogle Scholar
- Peled I, Shohat B, Gassner S, Kaplan I: Excision of epithelial tumors: CO2 laser versus conventional methods. Cancer Lett. 1976, 2: 41-45. 10.1016/S0304-3835(76)80009-2.View ArticlePubMedGoogle Scholar
- Capello V: Common surgical procedures in pet rodents. J Exot Pet Med. 2011, 20: 294-307. 10.1053/j.jepm.2011.07.002.View ArticleGoogle Scholar
- Bennett RA: Soft tissue surgery. Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. Edited by: Quesenberry KE, Carpenter JW. 2012, St. Louis: Elsevier Saunders, 373-391. 3View ArticleGoogle Scholar
- Meyers A: Complications of CO2 laser surgery of the larynx. Ann Otol Rhinol Laryngol. 1981, 90: 132-134.View ArticlePubMedGoogle Scholar
- Fried MP: Complications of CO2 laser surgery of the larynx. Laryngoscope. 1983, 93: 275-278.View ArticlePubMedGoogle Scholar
- Vilaseca-González I, Bernal-Sprekelsen M, Blanch-Alejandro JL, Moragas-Lluis M: Complications in transoral CO2 laser surgery for carcinoma of the larynx and hypopharynx. Head Neck. 2003, 25: 382-388. 10.1002/hed.10207.View ArticlePubMedGoogle Scholar
- Handa KK, Bhalla AP, Arora A: Fire during the use of Nd-Yag laser. Int J Pediatr Otorhinolaryngol. 2001, 60: 239-242. 10.1016/S0165-5876(01)00525-0.View ArticlePubMedGoogle Scholar
- Chou AK, Tan PH, Yang LC, Sun GC, Hsieh SW: Carbon dioxide laser induced airway fire during larynx surgery: case report. Chang Gung Med J. 2001, 24: 393-398.PubMedGoogle Scholar
- Berger N, Eeg PH: Veterinary laser surgery. 2006, Iowa: Blackwell Publishing AmesView ArticleGoogle Scholar
- Hernandez-Divers S: Diode laser surgery: Principles and application in exotic animals. Semin Avian Exot Pet Med. 2002, 11: 208-220. 10.1053/saep.2002.126575.View ArticleGoogle Scholar
- Snow JC, Norton ML, Saluja TS, Estanislao AF: Fire hazard during CO2 laser microsurgery on the larynx and trachea. Anesth Analg. 1976, 55: 146-147.View ArticlePubMedGoogle Scholar
- Komatsu T, Kaji R, Okazaki S, Miyawaki I, Ishihara K, Takahashi Y: Endotracheal tube ignition during the intratracheal laser treatment. Asian Cardiovasc Thorac Ann. 2008, 16: 49-51.View ArticleGoogle Scholar
- Santos P, Ayuso A, Luis M, Martínez G, Sala X: Airway ignition during CO2 laser laryngeal surgery and high frequency jet ventilation. Eur J Anaesthesiol. 2000, 17: 204-207.View ArticlePubMedGoogle Scholar
- Wang HM, Lee KW, Tsai CJ, Lu IC, Kuo WR: Tracheostomy tube ignition during microlaryngeal surgery using diode laser: a case report. Kaohsiung J Med Sci. 2006, 22: 199-202. 10.1016/S1607-551X(09)70308-0.View ArticlePubMedGoogle Scholar
- Rinder CS: Fire safety in the operating room. Curr Opinion Anaesthesiol. 2008, 21: 790-795. 10.1097/ACO.0b013e328318693a.View ArticleGoogle Scholar
- Blazquez E, Thorn C: Fires and explosions. Anaesth Intensive Care Med. 2010, 11: 455-457. 10.1016/j.mpaic.2010.08.007.View ArticleGoogle Scholar
- Williams DM, Littwin S, Patterson AJ, Brock-Utne JG: Fiberoptic light source induced surgical fires: the contribution of forced-air warming blankets. Acta Anesthesiol Scand. 2006, 50: 505-508. 10.1111/j.1399-6576.2006.00975.x.View ArticleGoogle Scholar
- Sesterhenn AM, Dunne AA, Braulke D, Lippert BM, Folz BJ, Werner JA: Value of endotracheal tube safety in laryngeal laser surgery. Lasers Surg Med. 2003, 32: 384-390. 10.1002/lsm.10174.View ArticlePubMedGoogle Scholar
- Walker P, Temperley A, Thelfo S, Hazelgrove A: Avoidance of laser ignition of endotracheal tubes by wrapping in aluminium foil tape. Anaesth Intensive Care. 2004, 32: 108-112.PubMedGoogle Scholar
- Shires CB, Saputra JM, King L, Thompson JW, Heck DH, Sebelik ME, Boughter JD: Histopathological and postoperative behavioral comparison of rodent oral tongue resection: fiber-enabled co2 laser versus electrocautery. Otolaryngol Head Neck Surg. In press
- Dhar V, Young K, Nouraei SA, Sandhu GS, Tatla T, Farrell R, Vaughan D, Sesterhenn AM, Dunne AA: Impact of oxygen concentration and laser power on occurrence of intraluminal fires during shared-airway surgery: an investigation. J Laryngol Otol. 2008, 122: 1335-1338. 10.1017/S0022215108003101.View ArticlePubMedGoogle Scholar
- Wolf GL, Sidebotham GW, Lazard JL, Charchaflieh JG: Laser ignition of surgical drape materials in air, 50% oxygen, and 95% oxygen. Anesthesiology. 2004, 100: 1167-1171. 10.1097/00000542-200405000-00019.View ArticlePubMedGoogle Scholar
- Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G: Prevention of atelectasis during general anaesthesia. Lancet. 1995, 345: 1387-1391. 10.1016/S0140-6736(95)92595-3.View ArticlePubMedGoogle Scholar
- Edmark L, Kostova-Aherdan K, Enlund M, Hedenstierna G: Optimal oxygen concentration during induction of general anesthesia. Anesthesiology. 2003, 98: 28-33. 10.1097/00000542-200301000-00008.View ArticlePubMedGoogle Scholar
- Edmark L, Auner U, Enlund M, Ostberg E, Hedenstierna G: Oxygen concentration and characteristics of progressive atelectasis formation during anaesthesia. Acta Anaesthesiol Scand. 2011, 55: 75-81. 10.1111/j.1399-6576.2010.02334.x.View ArticlePubMedGoogle Scholar
- Longley LA: Anaesthesia of Exotic Pets. 2008, Philadelphia: Saunders ElsevierGoogle Scholar
- Wenger S: Anesthesia and analgesia in rabbits and rodents. J Exot Pet Med. 2012, 21: 7-16. 10.1053/j.jepm.2011.11.010.View ArticleGoogle Scholar
- Dave R, Mahaffey PJ: The control of fire hazard during cutaneous laser therapy. Lasers Med Sci. 2002, 17: 6-8. 10.1007/s10103-002-8259-4.View ArticlePubMedGoogle Scholar
- Redrobe S: Soft tissue surgery of rabbits and rodents. Semin Avian Exot Pet Med. 2002, 11: 231-245. 10.1053/saep.2002.126570.View ArticleGoogle Scholar
- Smith JC, Bolon B: Isoflurane leakage from non-rebreathing rodent anaesthesia circuits: comparison of emissions from conventional and modified ports. Lab Anim. 2006, 40: 200-209. 10.1258/002367706776318999.View ArticlePubMedGoogle Scholar
- Hawkins MG, Pascoe PJ: Anesthesia, analgesia, and sedation of small mammals. Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. Edited by: Quesenberry KE, Carpenter JW. 2012, St. Louis: Elsevier Saunders, 429-451. 3View ArticleGoogle Scholar
- Batra S, Gupta R: Alcohol based surgical prep solution and the risk of fire in the operating room: a case report. Patient Saf Surg. 2008, 2: 10-10.1186/1754-9493-2-10.PubMed CentralView ArticlePubMedGoogle Scholar
- Roy S, Smith LP: What does it take to start an oropharyngeal fire? Oxygen requirements to start fires in the operating room. Int J Pediatr Otorhinolaryngol. 2011, 75: 227-230. 10.1016/j.ijporl.2010.11.005.View ArticlePubMedGoogle Scholar
- Patel R, Chavda KD, Hukkeri S: Surgical field fire and skin burns caused by alcohol-based skin preparation. J Emerg Trauma Shock. 2010, 3: 305-PubMed CentralView ArticlePubMedGoogle Scholar
- Arefiev K, Warycha M, Whiting D, Alam M: Flammability of topical preparations and surgical dressings in cutaneous and laser surgery: A controlled simulation study. J Am Acad Dermatol. In press
- Bennett RA, Mullen HS: Soft tissue surgery. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. Edited by: Quesenberry KE, Carpenter JW. 2004, St. Louis: Elsevier Saunders, 316-328. 2View ArticleGoogle Scholar
- Munksgaard AB, Bonde J, Valentin N: Ignition of the endotracheal tube during CO2 laser therapy of upper airway disorders. Ugeskr Laeger. 1805, 1991: 153-Google Scholar