Salivary mucoceles are uncommon salivary gland disorders in dogs that do not have breed or sex predilection . However, this condition is reported to be usually observed in French Poodles, German shepherd dogs, Dachshunds, and Australian Silky Terriers [3, 8]. Salivary mucoceles can be classified as subcutaneous, sublingual, pharyngeal, or periorbital salivary mucoceles according the anatomic location  and affected salivary gland/duct. They must be differentiated from sialoadenitis, sialoadenosis, salivary gland neoplasms, sialoliths, abscesses, foreign bodies, hematomas, enlarged lymph nodes, and congenital cysts since they are the major diseases that affect the salivary gland of the dog [5, 9, 10]. The only way to adequately differentiate between those processes is through histological analysis, consequently highlighting histopathology as an indispensable method for reaching the correct diagnosis . Microscopically, salivary mucoceles can occasionally reveal the presence of metaplastic lesions such as osteoid metaplasia; however, this condition seems to be a rare lesion in dogs and other species of veterinary interest because few cases have been reported to date [6, 7]. Despite this, it is still possible to correctly suggest the occurrence of a salivary mucocele based on the presenting clinical signs (fluctuant, thin-walled lesion in the sublingual, intermandibular/cervical, or pharyngeal region) and other clinical findings such as aspiration of saliva-like fluid that may be transparent, but more often has a brownish color. Metaplastic lesions are presumptive reversible changes in which one adult cell type is replaced by another adult cell type. This lesion may also represent an adaptive substitution of cells more sensitive to stress by cell types that are better able to withstand an adverse environment. In cases of osteoid metaplasia, the condition is suggested to occur in fibrous connective tissue cells that undergo osteogenic differentiation and give rise to bone where it is normally not present . This process is a subtype of ectopic ossification, which has two other subtypes: heterotopic ossification and osseous choristoma. Osseous choristoma is a lesion that is microscopically characterized by normal bone in abnormal sites . On the other hand, heterotopic ossification is an alteration that usually occurs as secondary to metastatic mineralization from systemic disease or dystrophic mineralization . Ectopic ossification can occur virtually anywhere [11–17] and, although being rare in salivary glands, has been reported in dogs with salivary mucocele presenting as OM [6, 7]. In the present case, only mesenchymal cells undergoing osteogenic cell differentiation could be observed in the wall of the salivary mucocele and evidence neither from metastatic nor dystrophic mineralization were detected, similarly to what was found by other authors [6, 7]. In this case, salivary sialoliths were grossly and microscopically observed. Such sialoliths can develop as a result of deposition of mineral salts around a nidus of bacteria, mucus, or desquamated cells . Salivary stagnation, increased alkalinity of the saliva, increased calcium content of the saliva, infection or inflammation of the salivary duct or gland, and physical trauma to the salivary duct or gland may predispose to sialolith formation [18, 19]. The pathogenesis of the process observed in the present case was not clearly understood; however, trauma and chronic inflammation could be considered as possible causes, since sialoliths and foreign bodies have been considered to be etiological agents in the development of salivary mucoceles in dogs [20, 21]. There are only two reported cases of osteoid metaplasia salivary mucoceles in dogs to date [6, 7], none of them in the Shih Tzu dog. This case report highlights a rare peculiarity within a salivary mucocele in a dog but due to the rarity and lack of information about this specific disease, no clinical data can yet be associated with the development of salivary mucocele with osseous metaplasia in dogs.