Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters

BMC Veterinary Research

Table 1 Survival times of hamsters that underwent regional lymphadenectomy after scrapie infection

	Sham operation 6 days after infection		Ectomy 4 h after infection		Ectomy 24 h after infection		Ectomy 2 days after infection		Ectomy 6 days after infection
	individual survival	mean ± SD	individual survival	mean ± SD	individual survival	mean ± SD	individual survival	mean ± SD	individual survival;	mean ± SD
Infectious dose: 20 μl 1% 263K-homogenate	108; 108; 121; 121; 121; 121	117 ± 7	111; 111; 108; 114; 114; 118	113 ± 3; p ≤ 0.25	104; 108; 108; 111; 114; 114	110 ± 4 p ≤ 0.1	108; 111; 114; 114; 114; 118	113 ± 3 p ≤ 0.5	93; 108; 108; 111; 114; 118	109 ± 9; p ≤ 0.1
Infectious dose: 20 μl 0.01% 263K-homogenate	108; 111; 115; 118	113 ± 4	100; 108; 111; 115; 118; 115	111 ± 7; p ≤ 1.0	111; 115; 118; 121; 174	128 ± 26; p ≤ 0.5	118; 118; 121; 132; 178	133 ± 26; p ≤ 0.25	115; 115; 125; 125; 128; 128	123 ± 6; p ≤ 0.05*

Individual survival times, i. e. the interval of time between incoculation and the occurrence of terminal disease (days), mean survival times (days ± SD) and p-values (levels of significance as determined vs. the sham-operated control groups) of hamsters that underwent regional lymphadenectomy of the Ln. popliteus at the indicated time points following inoculation of a high or a low dose of 263K scrapie agent into the footpad. Sham operations were performed at 6 dpi. Asterisk indicates a statistically significant increase of the mean incubation time as compared to the sham-operated control group (p = 0.05, Student's unpaired two-tailed t-Test).
Note: Individual incubation times until the onset of clinical symptoms (not shown) were approximately 8–14 days shorter than the reported survival times.

ISSN: 1746-6148